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Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism
(Society for Endocrinology, 2016-07-01)
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis. This study ...
-α-synuclein overexpression triggers a lipid metabolic switch: lipid droplets as an early marker of neurodegeneration
(Sociedad Argentina de Investigación en Neurociencias, 2018)
Pathological accumulation of α-synuclein (α-syn) is a hallmark of Parkinson ‘s disease. α-syn is highly expressed in the brain and has the intriguing characteristic of interacting with lipids. However, little is known about ...
Activation of peroxisome proliferator nuclear receptors regulates lipid metabolism in the placenta
(Galenos Yayincilik, 2007-09)
OBJECTIVE: Peroxisome proliferator activated receptors (PPARs), known regulators of lipid homeostasis in different tissues, are crucial during placental development. In this work we aim to determine whether PPARs activation ...
Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications
(Frontiers Media S.A., 2019-05-01)
Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation ...
A descriptive study of the occurrence and significance of lipids in Taenia hydatigena eggs
(Elsevier Science, 2010-04)
The aim of this work was to investigate the lipid content of Taenia hydatigena eggs and to evaluate the role of lipids in the maintenance of embryo viability. The total lipid content of the egg was 4.5% (w/w). Five classes ...
PPARalpha agonists regulate lipid metabolism and nitric oxide production and prevents placental overgrowth in tern in placentas from diabetic rats
(BioScientifica, 2011-06)
Maternal diabetes impairs fetoplacental metabolism and growth. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor capable of regulating lipid metabolism and inflammatory pathways. In this study, we ...
Comprehensive analysis of a metabolic model for lipid production in Rhodosporidium toruloides
(Elsevier Science, 2018-08)
The yeast Rhodosporidium toruloides has been extensively studied for its application in biolipid production. The knowledge of its metabolism capabilities and the application of constraint-based flux analysis methodology ...
α-Synuclein and lipid metabolism: intersecting pathways
(Tech Science Press, 2019)
α-synuclein (α-syn) aggregation and fibrillation is a hallmark of a class of neurodegenerative disorders known as synucleinopathies. An intriguing and not completely clarified feature of α-syn is the many ways in which it ...
Nuclear-lipid-droplet proteome: carboxylesterase as a nuclear lipase involved in lipid-droplet homeostasis
(Elsevier, 2021-03)
Nuclear-lipid droplets (nLD)—a dynamic cellular organelle that stores neutral lipids, within the nucleus of eukaryotic cells—consists of a hydrophobic triacylglycerol –cholesterol-ester core enriched in oleic acid (OA) ...
Lipid Droplets: Structure, Composition, Formation and Function. Connection with the Endoplasmic Reticulum
(Nova Science Publishers, 2019)
Fatty acids (FAs) are important compounds either used for energy production through β-oxidation, for membrane lipid synthesis, or for production of lipid mediators (oxylipins) through oxidations. FAs are also cytotoxic and ...